1.Fulcher ML, Gabriel S, Burns KA, et al. Effectively-differentiated human airway epithelial cell cultures. Strategies Mol Med. 2005;107:183–206.2.Bals R, Hiemstra PS. Innate immunity within the lung: how epithelial cells battle towards respiratory pathogens. Eur Respir J. 2004;23:327–33.three.Parker D, Prince A. Innate immunity within the respiratory epithelium. Am J Respir Cell Mol Biol. 2011;45:189–201.four.Wesley UV, Bove PF, Hristova M, et al. Airway epithelial cell migration and wound restore by ATP-mediated activation of twin oxidase 1. J Biol Chem. 2007;282:3213–20.5.Perotin JM, Adam D, Vella-Boucaud J, et al. Delay of airway epithelial wound restore in COPD is related to airflow obstruction severity. Respir Res. 2014;15:151.6.Whitcutt MJ, Adler KB, Wu R. A biphasic chamber system for sustaining polarity of differentiation of cultured respiratory tract epithelial cells. Vitr Cell Dev Biol. 1988;24:420–Eight.7.Ashraf S, Brockman-Schneider R, Bochkov YA, et al. Organic traits and propagation of human rhinovirus-C in differentiated sinus epithelial cells. Virology. 2013;436:143–9.Eight.Ashraf S, Brockman-Schneider R, Gern JE. Propagation of rhinovirus-C strains in human airway epithelial cells differentiated at air-liquid interface. Strategies Mol Biol. 2015;1221:63–70.9.Krunkosky TM, Jordan JL, Chambers E, et al. Mycoplasma pneumoniae host-pathogen research in an air-liquid tradition of differentiated human airway epithelial cells. Microb Pathog. 2007;42:98–103.10.Thaikoottathil JV, Martin RJ, Zdunek J, et al. Cigarette smoke extract reduces VEGF in major human airway epithelial cells. Eur Respir J. 2009;33:835–43.11.Berube Okay, Prytherch Z, Job C, et al. Human major bronchial lung cell constructs: the brand new respiratory fashions. Toxicology. 2010;278:311–Eight.12.Dvorak A, Tilley AE, Shaykhiev R, et al. Do airway epithelium air-liquid cultures characterize the in vivo airway epithelium transcriptome? Am J Respir Cell Mol Biol. 2011;44:465–73.13.Prytherch Z, Job C, Marshall H, et al. Tissue-Particular stem cell differentiation in an in vitro airway mannequin. Macromol Biosci. 2011;11:1467–77.14.Ostrowski LE, Stewart D, Hazucha M. Interferon gamma stimulates accumulation of fuel part nitric oxide in differentiated cultures of regular and cystic fibrosis airway epithelial cells. Lung. 2012;190:563–71.15.Comer DM, Kidney JC, Ennis M, et al. Airway epithelial cell apoptosis and irritation in COPD, people who smoke and nonsmokers. Eur Respir J. 2013;41:1058–67.16.Damian S, Klarmann G, Smithhisler M. B-ALI(TM) Bronchial air liquid interface media equipment, a assured 3D in vitro mannequin for respiratory analysis. Lonza Useful resource Notes 2010;Fall 2010:13–16.17.Hao W, Bernard Okay, Patel N, et al. An infection and propagation of human rhinovirus C in human airway epithelial cells. J Virol. 2012;86:13524–32.18.Hill DB, Button B. Institution of respiratory air-liquid interface cultures and their use in finding out mucin manufacturing, secretion, and performance. Strategies Mol Biol. 2012;842:245–58.19.Ong HX, Jackson CL, Cole JL, et al. Major air-liquid interface tradition of nasal epithelium for nasal drug supply. Mol Pharm. 2016;13:2242–52.20.Stevens PT, Kicic A, Sutanto EN, et al. Dysregulated restore in asthmatic paediatric airway epithelial cells: the function of plasminogen activator inhibitor-1. Clin Exp Allergy. 2008;38:1901–10.21.Kicic A, Hallstrand TS, Sutanto EN, et al. Decreased fibronectin manufacturing considerably contributes to dysregulated restore of asthmatic epithelium. Am J Respir Crit Care Med. 2010;181:889–98.22.Barrow RE, Wang CZ, Evans MJ, et al. Progress components speed up epithelial restore in sheep trachea. Lung. 1993;171:335–44.23.Takeyama Okay, Dabbagh Okay, Lee HM, et al. Epidermal development issue system regulates mucin manufacturing in airways. Proc Natl Acad Sci USA. 1999;96:3081–6.24.Schettino C, Bareschino MA, Ricci V, et al. Erlotinib: an EGF receptor tyrosine kinase inhibitor in non-small-cell lung most cancers remedy. Knowledgeable Rev Respir Med. 2008;2:167–78.25.Spann KM, Baturcam E, Schagen J, et al. Viral and host components decide innate immune responses in airway epithelial cells from kids with wheeze and atopy. Thorax. 2014;69:918–25.26.Muller L, Brighton LE, Carson JL, et al. Culturing of human nasal epithelial cells on the air liquid interface. J Vis Exp. 2013;e50646:1–7.27.Parker JC, Douglas I, Bell J, et al. Epidermal development issue removing or tyrphostin AG1478 remedy reduces goblet cells & mucus secretion of epithelial cells from asthmatic kids utilizing the air-liquid interface mannequin. PLoS ONE. 2015;10:e0129546.28.Zaidman NA, Panoskaltsis-Mortari A, O’Grady SM. Differentiation of human bronchial epithelial cells: function of hydrocortisone in improvement of ion transport pathways concerned in mucociliary clearance. Am J Physiol Cell Physiol. 2016;311:C225–36.29.Gras D, Chanez P, Vachier I, et al. Bronchial epithelium as a goal for modern therapies in bronchial asthma. Pharmacol Ther. 2013;140:290–305.30.Comer DM, Elborn JS, Ennis M. Comparability of nasal and bronchial epithelial cells obtained from sufferers with COPD. PLoS ONE. 2012;7:e32924.31.Rock JR, Randell SH, Hogan BL. Airway basal stem cells: a perspective on their roles in epithelial homeostasis and reworking. Dis Mannequin Mech. 2010;three:545–56.32.Warner SM, Hackett TL, Shaheen F, et al. Transcription issue p63 regulates key genes and wound restore in human airway epithelial basal cells. Am J Respir Cell Mol Biol. 2013;49:978–88.33.Wan H, Kaestner KH, Ang SL, et al. Foxa2 regulates alveolarization and goblet cell hyperplasia. Growth. 2004;131:953–64.34.Wanner A, Salathe M, O’Riordan TG. Mucociliary clearance within the airways. Am J Respir Crit Care Med. 1996;154:1868–902.35.Lu JJ, Xu GN, Yu P, et al. The activation of M3 mAChR in airway epithelial cells promotes IL-Eight and TGF-beta1 secretion and airway clean muscle cell migration. Respir Res. 2016;17:25.36.Crosby LM, Waters CM. Epithelial restore mechanisms within the lung. Am J Physiol Lung Cell Mol Physiol. 2010;298:L715–731.37.Gardner A, Borthwick LA, Fisher AJ. Lung epithelial wound therapeutic in well being and illness. Knowledgeable Rev Respir Med. 2010;four:647–60.38.Xiao H, Li DX, Liu M. Data translation: airway epithelial cell migration and respiratory ailments. Cell Mol Life Sci. 2012;69:4149–62.39.Grainge CL, Davies DE. Epithelial harm and restore in airways ailments. Chest. 2013;144:1906–12.40.Zaja-Milatovic S, Richmond A. CXC chemokines and their receptors: a case for a big organic function in cutaneous wound therapeutic. Histol Histopathol. 2008;23:1399–407.41.Arwert EN, Hoste E, Watt FM. Epithelial stem cells, wound therapeutic and most cancers. Nat Rev Most cancers. 2012;12:170–80.42.Vliagoftis H, Befus AD, Hollenberg MD, et al. Airway epithelial cells launch eosinophil survival-promoting components (GM-CSF) after stimulation of proteinase-activated receptor 2. J Allergy Clin Immunol. 2001;107:679–85.43.Allahverdian S, Harada N, Singhera GK, et al. Secretion of IL-13 by airway epithelial cells enhances epithelial restore by way of HB-EGF. Am J Respir Cell Mol Biol. 2008;38:153–60.44.Spurrell JCL, Wiehler S, Zaheer RS, et al. Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus an infection. Am J Physiol-Lung Cell Mol Physiol. 2005;289:L85–95.45.Tanaka T, Narazaki M, Kishimoto T. IL-6 in irritation, immunity, and illness. Chilly Spring Harb Perspect Biol. 2014;6:a016295.46.Coraux C, Martinella-Catusse C, Nawrocki-Raby B, et al. Differential expression of matrix metalloproteinases and interleukin-Eight throughout regeneration of human airway epithelium in vivo. J Pathol. 2005;206:160–9.47.Burgel PR, Nadel JA. Roles of epidermal development issue receptor activation in epithelial cell restore and mucin manufacturing in airway epithelium. Thorax. 2004;59:992–6.48.Prasad R, Giri S, Nath N, et al. Inhibition of phosphoinositide three kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interplay. J Neurochem. 2005;94:204–14.49.Jaspers I, Horvath KM, Zhang W, et al. Decreased expression of IRF7 in nasal epithelial cells from people who smoke after an infection with influenza. Am J Respir Cell Mol Biol. 2010;43:368–75.50.McDougall CM, Blaylock MG, Douglas JG, et al. Nasal epithelial cells as surrogates for bronchial epithelial cells in airway irritation research. Am J Respir Cell Mol Biol. 2008;39:560–Eight.