ObjectivesTo report how peak inflating stress (PIP), tidal quantity (VT) and low-tidal quantity alarms are affected by most allowed inflating stress (Pmax) throughout quantity assure (VG) air flow.Examine designVentilation information had been analysed with 1 Hz sampling price from 25 neonates receiving synchronised intermittent optimistic stress air flow with VG for >12 h.ResultsThe distinction between Pmax and PIP (Pdiff) ranged between 5 and 20 mbar (median = 11 mbar) regardless of a protocol to maintain Pmax 5 mbar above the “working PIP”. Pmax was reached in 5.2% of inflations. Computational modelling demonstrated that had Pdiff been stored at 5 mbar extra persistently, >10% of inflations would have reached Pmax. The frequency of low-tidal quantity alarms confirmed inverse correlation with Pdiff.ConclusionsIt is tough to implement a easy Pmax technique because of variability of PIP. Setting Pmax near the “working PIP” limits VT supply and triggers frequent alarms.