1.Vogelmeier, C. F. et al. International Technique for the Prognosis, Administration, and Prevention of Power Obstructive Lung Illness 2017 Report: GOLD Govt Abstract. The European respiratory journal: official journal of the European Society for Scientific Respiratory Physiology 49, https://doi.org/10.1183/13993003.00214-2017 (2017).2.Pitta, F. et al. Traits of bodily actions in every day life in power obstructive pulmonary illness. American journal of respiratory and important care drugs 171, 972–977, https://doi.org/10.1164/rccm.200407-855OC (2005).three.Ofir, D., Laveneziana, P., Webb, Ok. A., Lam, Y. M. & O’Donnell, D. E. Mechanisms of dyspnea throughout cycle train in symptomatic sufferers with GOLD stage I power obstructive pulmonary illness. American journal of respiratory and important care drugs 177, 622–629, https://doi.org/10.1164/rccm.200707-1064OC (2008).four.Guenette, J. A. et al. Intercourse variations in exertional dyspnea in sufferers with gentle COPD: physiological mechanisms. Respiratory physiology & neurobiology 177, 218–227, https://doi.org/10.1016/j.resp.2011.04.011 (2011).5.Elbehairy, A. F. et al. Pulmonary Fuel Trade Abnormalities in Gentle Power Obstructive Pulmonary Illness. Implications for Dyspnea and Train Intolerance. American journal of respiratory and important care drugs 191, 1384–1394, https://doi.org/10.1164/rccm.201501-Zero157OC (2015).6.Neder, J. A. et al. Train ventilatory inefficiency in gentle to end-stage COPD. The European respiratory journal: official journal of the European Society for Scientific Respiratory Physiology 45, 377–387, https://doi.org/10.1183/09031936.00135514 (2015).7.Chin, R. C. et al. Does the respiratory system restrict train in gentle power obstructive pulmonary illness? American journal of respiratory and important care drugs 187, 1315–1323, https://doi.org/10.1164/rccm.201211-1970OC (2013).eight.Agusti, A., Celli, B. & Faner, R. What does endotyping imply for therapy in power obstructive pulmonary illness? Lancet 390, 980–987, https://doi.org/10.1016/S0140-6736(17)32136-Zero (2017).9.The definition of emphysema. Report of a Nationwide Coronary heart, Lung, and Blood Institute, Division of Lung Illnesses workshop. Am Rev Respir Dis 132, 182–185 (1985).10.Gevenois, P. A., de Maertelaer, V., De Vuyst, P., Zanen, J. & Yernault, J. C. Comparability of computed density and macroscopic morphometry in pulmonary emphysema. American journal of respiratory and important care drugs 152, 653–657, https://doi.org/10.1164/ajrccm.152.2.7633722 (1995).11.Gevenois, P. A. et al. Comparability of computed density and microscopic morphometry in pulmonary emphysema. American journal of respiratory and important care drugs 154, 187–192, https://doi.org/10.1164/ajrccm.154.1.8680679 (1996).12.Oelsner, E. C. et al. Affiliation between emphysema-like lung on cardiac computed tomography and mortality in individuals with out airflow obstruction: a cohort examine. Ann Intern Med 161, 863–873, https://doi.org/10.7326/M13-2570 (2014).13.Oelsner, E. C. et al. Per cent emphysema is related to respiratory and lung most cancers mortality within the normal inhabitants: a cohort examine. Thorax 71, 624–632, https://doi.org/10.1136/thoraxjnl-2015-207822 (2016).14.Barr, R. G. et al. % emphysema, airflow obstruction, and impaired left ventricular filling. N Engl J Med 362, 217–227, https://doi.org/10.1056/NEJMoa0808836 (2010).15.Smith, B. M. et al. Impaired left ventricular filling in COPD and emphysema: is it the center or the lungs? The Multi-Ethnic Research of Atherosclerosis COPD Research. Chest 144, 1143–1151, https://doi.org/10.1378/chest.13-0183 (2013).16.Kawut, S. M. et al. Cor pulmonale parvus in power obstructive pulmonary illness and emphysema: the MESA COPD examine. J Am Coll Cardiol 64, 2000–2009, https://doi.org/10.1016/j.jacc.2014.07.991 (2014).17.Hueper, Ok. et al. Pulmonary Microvascular Blood Stream in Gentle Power Obstructive Pulmonary Illness and Emphysema. The MESA COPD Research. American journal of respiratory and important care drugs 192, 570–580, https://doi.org/10.1164/rccm.201411-2120OC (2015).18.Wakayama, Ok., Kurihara, N., Fujimoto, S., Hata, M. & Takeda, T. Relationship between train capability and the severity of emphysema as decided by excessive decision CT. The European respiratory journal: official journal of the European Society for Scientific Respiratory Physiology 6, 1362–1367 (1993).19.Lee, Y. Ok. et al. Quantitative evaluation of emphysema, air trapping, and airway thickening on computed tomography. Lung 186, 157–165, https://doi.org/10.1007/s00408-Zero08-9071-Zero (2008).20.Yamasawa, W., Tasaka, S., Betsuyaku, T. & Yamaguchi, Ok. Correlation of a Decline in Cardio Capability with Growth of Emphysema in Sufferers with Power Obstructive Pulmonary Illness: A Potential Observational Research. PLoS One 10, e0125053, https://doi.org/10.1371/journal.pone.0125053 (2015).21.Jones, J. H. et al. Emphysema on Thoracic CT and Train Ventilatory Inefficiency in Gentle-to-Average COPD. Copd 14, 210–218, https://doi.org/10.1080/15412555.2016.1253670 (2017).22.Crisafulli, E. et al. Relationships between emphysema and airways metrics at Excessive-Decision Computed Tomography (HRCT) and ventilatory response to train in gentle to average COPD sufferers. Respiratory drugs 117, 207–214, https://doi.org/10.1016/j.rmed.2016.06.016 (2016).23.Smith, B. M. et al. Pulmonary emphysema subtypes on computed tomography: the MESA COPD examine. The American journal of drugs 127, 94 e97–23, https://doi.org/10.1016/j.amjmed.2013.09.020 (2014).24.Paoletti, P. et al. Cardiopulmonary train testing (CPET) in pulmonary emphysema. Respiratory physiology & neurobiology 179, 167–173, https://doi.org/10.1016/j.resp.2011.07.Zero13 (2011).25.Diaz, A. A. et al. Relationship of emphysema and airway illness assessed by CT to train capability in COPD. Respiratory drugs 104, 1145–1151, https://doi.org/10.1016/j.rmed.2010.02.Zero23 (2010).26.Diaz, A. A. et al. CT and physiologic determinants of dyspnea and train capability through the six-minute stroll check in gentle COPD. Respiratory drugs 107, 570–579, https://doi.org/10.1016/j.rmed.2012.12.011 (2013).27.Diaz, A. A. et al. Emphysema and DLCO predict a clinically essential distinction for 6MWD decline in COPD. Respiratory drugs 109, 882–889, https://doi.org/10.1016/j.rmed.2015.04.009 (2015).28.Andrianopoulos, V. et al. Determinants of exercise-induced oxygen desaturation together with pulmonary emphysema in COPD: Outcomes from the ECLIPSE examine. Respiratory drugs 119, 87–95, https://doi.org/10.1016/j.rmed.2016.08.Zero23 (2016).29.Kirby, M. et al. COPD: Do Imaging Measurements of Emphysema and Airway Illness Clarify Signs and Train Capability? Radiology 277, 872–880, https://doi.org/10.1148/radiol.2015150037 (2015).30.Wagner, P. D., Dantzker, D. R., Dueck, R., Clausen, J. L. & West, J. B. Air flow-perfusion inequality in power obstructive pulmonary illness. J Clin Make investments 59, 203–216, https://doi.org/10.1172/JCI108630 (1977).31.Burrows, B., Fletcher, C. M., Heard, B. E., Jones, N. L. & Wootliff, J. S. The emphysematous and bronchial varieties of power airways obstruction. A clinicopathological examine of sufferers in London and Chicago. Lancet 1, 830–835 (1966).32.Chaouat, A. et al. Extreme pulmonary hypertension and power obstructive pulmonary illness. American journal of respiratory and important care drugs 172, 189–194, https://doi.org/10.1164/rccm.200401-Zero06OC (2005).33.Adir, Y., Shachner, R., Amir, O. & Humbert, M. Extreme pulmonary hypertension related to emphysema: a brand new phenotype? Chest 142, 1654–1658, https://doi.org/10.1378/chest.11-2816 (2012).34.Sanders, Ok. J. C., Klooster, Ok., Vanfleteren, L., Slebos, D. J. & Schols, A. CT-derived muscle remodelling after bronchoscopic lung quantity discount in superior emphysema. Thorax. https://doi.org/10.1136/thoraxjnl-2018-211931 (2018).35.Vanfleteren, L. E. et al. Clusters of comorbidities based mostly on validated goal measurements and systemic irritation in sufferers with power obstructive pulmonary illness. Am J Respir Crit Care Med 187, 728–735, https://doi.org/10.1164/rccm.201209-1665OC (2013).36.McDonald, M. L. et al. Quantitative computed tomography measures of pectoralis muscle space and illness severity in power obstructive pulmonary illness. A cross-sectional examine. Annals of the American Thoracic Society 11, 326–334, https://doi.org/10.1513/AnnalsATS.201307-229OC (2014).37.Wells, J. M. et al. Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med 367, 913–921, https://doi.org/10.1056/NEJMoa1203830 (2012).38.Iyer, Ok. S. et al. Quantitative Twin-Vitality Computed Tomography Helps a Vascular Etiology of Smoking-induced Inflammatory Lung Illness. American journal of respiratory and important care drugs 193, 652–661, https://doi.org/10.1164/rccm.201506-1196OC (2016).39.Bhatt, S. P. et al. beta-Blockers for the prevention of acute exacerbations of power obstructive pulmonary illness (betaLOCK COPD): a randomised managed examine protocol. BMJ Open 6, e012292, https://doi.org/10.1136/bmjopen-2016-012292 (2016).40.Yang, L. et al. Mechanisms of Vascular Dysfunction in COPD and Results of a Novel Soluble Epoxide Hydrolase Inhibitor in People who smoke. Chest 151, 555–563, https://doi.org/10.1016/j.chest.2016.10.058 (2017).41.O’Donnell, D. E., D’Arsigny, C., Fitzpatrick, M. & Webb, Ok. A. Train hypercapnia in superior power obstructive pulmonary illness: the position of lung hyperinflation. Am J Respir Crit Care Med 166, 663–668, https://doi.org/10.1164/rccm.2201003 (2002).42.Gagnon, P. et al. Influences of spinal anesthesia on train tolerance in sufferers with power obstructive pulmonary illness. Am J Respir Crit Care Med 186, 606–615, https://doi.org/10.1164/rccm.201203-0404OC (2012).43.Gevenois, P. A. et al. The consequences of age, intercourse, lung dimension, and hyperinflation on CT lung densitometry. AJR Am J Roentgenol 167, 1169–1173, https://doi.org/10.2214/ajr.167.5.8911175 (1996).44.Miller, M. R. et al. Standardisation of spirometry. The European respiratory journal: official journal of the European Society for Scientific Respiratory Physiology 26, 319–338, https://doi.org/10.1183/09031936.05.00034805 (2005).45.Wanger, J. et al. Standardisation of the measurement of lung volumes. The European respiratory journal: official journal of the European Society for Scientific Respiratory Physiology 26, 511–522, https://doi.org/10.1183/09031936.05.00035005 (2005).46.Macintyre, N. et al. Standardisation of the single-breath willpower of carbon monoxide uptake within the lung. The European respiratory journal: official journal of the European Society for Scientific Respiratory Physiology 26, 720–735, https://doi.org/10.1183/09031936.05.00034905 (2005).47.Hankinson, J. L., Odencrantz, J. R. & Fedan, Ok. B. Spirometric reference values from a pattern of the final U.S. inhabitants. American journal of respiratory and important care drugs 159, 179–187, https://doi.org/10.1164/ajrccm.159.1.9712108 (1999).48.Crapo, R. O. & Morris, A. H. Standardized single breath regular values for carbon monoxide diffusing capability. Am Rev Respir Dis 123, 185–189, https://doi.org/10.1164/arrd.19126.96.36.199 (1981).49.Crapo, R. O., Morris, A. H., Clayton, P. D. & Nixon, C. R. Lung volumes in wholesome nonsmoking adults. Bull Eur Physiopathol Respir 18, 419–425 (1982).50.American Thoracic, S. & American Faculty of Chest, P. ATS/ACCP Assertion on cardiopulmonary train testing. American journal of respiratory and important care drugs 167, 211–277, https://doi.org/10.1164/rccm.167.2.211 (2003).51.Borg, G. A. Psychophysical bases of perceived exertion. Med Sci Sports activities Exerc 14, 377–381 (1982).52.Jones, N. L., Makrides, L., Hitchcock, C., Chypchar, T. & McCartney, N. Regular requirements for an incremental progressive cycle ergometer check. Am Rev Respir Dis 131, 700–708, https://doi.org/10.1164/arrd.19188.8.131.520 (1985).