Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Writer notesA full checklist of members and affiliations seems within the Supplementary Notice.Florence Demenais, Patricia Margaritte-Jeannin, Kathleen C. Barnes, William O. C. Cookson, Miriam F. Moffatt, Carole Ober and Dan Nicolae contributed equally to this work.AffiliationsGenetic Variation and Human Illnesses Unit (UMR-946), Institut Nationwide de la Santé et de la Recherche Médicale (INSERM), Paris, FranceFlorence Demenais, Patricia Margaritte-Jeannin, Emmanuelle Bouzigon, Myriam Brossard, Sébastien Letort, Hamida Mohamdi & Amaury VaysseInstitut Universitaire d’Hématologie, Université Paris Diderot, Université Sorbonne Paris Cité, Paris, FranceFlorence Demenais, Patricia Margaritte-Jeannin, Emmanuelle Bouzigon, Myriam Brossard, Sébastien Letort, Hamida Mohamdi & Amaury VaysseDivision of Biomedical Informatics and Personalised Drugs, Colorado Middle for Personalised Drugs, College of Colorado, Denver, CO, USASection of Genomic Drugs, Nationwide Coronary heart and Lung Institute, London, UKWilliam O. C. Cookson & Miriam F. MoffattCologne Middle for Genomics and Middle for Molecular Drugs Cologne (CMMC), College of Cologne, Cologne, GermanySchool of Ladies’s and Infants’ Well being, College of Western Australia, Perth, Western Australia, AustraliaWei Ang & Craig E. PennellDepartments of Drugs and Epidemiology, Columbia College, New York, NY, USAR. Graham Barr & Kathleen M. DonohueDivision of Genetic Epidemiology, Division of Epidemiology, Bloomberg College of Public Well being, Johns Hopkins College, Baltimore, MD, USADepartment of Pediatrics and Youngster Well being, College of Manitoba, Winnipeg, Manitoba, CanadaDepartment of the Diagnostic Genomics Laboratory, PathWest Laboratory Drugs, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, AustraliaJohn Beilby & Jennie HuiCopenhagen Potential Research on Bronchial asthma in Childhood, Herlev and Gentofte Hospital, College of Copenhagen, Copenhagen, DenmarkHans Bisgaard, Klaus Bønnelykke, Eskil Kreiner & Johannes WaageDepartment of Drugs, Landspitali, Nationwide College Hospital of Iceland, Reykjavik, IcelandUnnur Steina BjornsdottirCenter for Genomics, Wake Forest College College of Drugs, Winston-Salem, NC, USAEugene Bleecker & Deborah MeyersDepartment of Organic Psychology, Amsterdam Public Well being Analysis Institute, Vrjie Universiteit, Amsterdam, The NetherlandsDorret I. Boomsma, Jouke Hottenga, Hamdi Mbarek & Gonneke WillemsenUniversity of Leicester, Institute for Lung Well being, Glenfield Hospital, Leicester, UKChristopher E. BrightlingDepartment of Respiratory Drugs, Ghent College Hospital, Ghent, BelgiumDepartment of Epidemiology, Erasmus MC–College Medical Middle Rotterdam, Rotterdam, The NetherlandsGuy G. Brusselle, Albert Hofman, Lies Lahousse, Daan W. Loth & Bruno H. StrickerDepartment of Respiratory Drugs, Erasmus MC–College Medical Middle Rotterdam, Rotterdam, The NetherlandsDepartment of Bioengineering & Therapeutic Sciences and Drugs, College of California, San Francisco, San Francisco, CA, USADivision of Pulmonary, Allergy and Essential Care, School of Physicians and Surgeons, Columbia College, New York, NY, USANational Coronary heart and Lung Institute, Imperial School London, London, UKAndrew Bush, Kian Fan Chung & Deborah JarvisRoyal Brompton Harefield Nationwide Well being Service (NHS) Basis Belief, London, UKDepartment of Drugs, College of British Columbia, Vancouver, British Columbia, CanadaMoira Chan-Yeung, Denise Daley & Julie E. ParkBiomedical Analysis Unit, Royal Brompton & Harefield Nationwide Well being Service (NHS) Belief, London, UKDepartment of Epidemiology and Biostatistics, Imperial School London, London, UKAlexessander Couto Alves & Adaikalavan RamasamyDivision of An infection, Immunity and Respiratory Drugs, College of Organic Sciences, School of Biology, Drugs and Well being, Manchester Educational Well being Science Centre, College of Manchester, Manchester, UKJohn A. Curtin & Angela SimpsonDepartment of Paediatrics, Imperial School London, London, UKCentre for Coronary heart and Lung Innovation, College of British Columbia, Vancouver, BC, CanadaDepartment of Pediatrics, Division of Respiratory Drugs, Erasmus MC–College Medical Middle Rotterdam, Rotterdam, The NetherlandsHospital Infantil de Mexico Federico Gomez, Mexico Metropolis, MexicoBlanca E. Del-Rio-NavarroDepartment of Pediatrics, Division of Respiratory Drugs, and Division of Pediatrics, Division of Neonatology, Erasmus MC–College Medical Middle Rotterdam, Rotterdam, The NetherlandsDepartment of Drugs, College of California, San Francisco, San Francisco, CA, USACeleste Eng & Dara G. TorgersonDepartment of Common Apply and Main Well being Care, College of Helsinki and Helsinki College Hospital, Helsinki, FinlandDivision of Cardiovascular Drugs, Radcliffe Division of Drugs, College of Oxford, Oxford, UKWellcome Belief Centre for Human Genetics, College of Oxford, Oxford, UKInstitute of Biochemistry and Genetics, Ufa Scientific Middle of the Russian Academy of Sciences, Ufa, Russian FederationYuliya Fedorova, Alexandra S. Karunas & Elza KhusnutdinovaDepartment of Epidemiology Analysis, Statens Serum Institut, Copenhagen, DenmarkBjarke Feenstra, Frank Geller & Mads MelbyeGenetics and Computational Biology, QIMR Berghofer Medical Analysis Institute, Brisbane, Queensland, AustraliaPopulation Genetics Laboratory, Analysis Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russian FederationMaxim B. Freidin & Valery P. PuzyrevDivisions of Genetics and Endocrinology, Youngsters’s Hospital, Boston, MA, USAZofia Gajdos & Sailaja VedantamBroad Institute, Cambridge, MA, USAZofia Gajdos, Joel N. Hirschhorn, Cameron D. Palmer & Sailaja VedantamDepartment of Preventive Drugs, Keck College of Drugs, College of Southern California, Los Angeles, CA, USAJim Gauderman, Frank Gilliland & Muhammad T. SalamDivision of Environmental Epidemiology, Institute for Danger Evaluation Sciences, Utrecht College, Utrecht, The NetherlandsUlrike Gehring, Dick Heederik & Inge M. WoutersInstitute of Epidemiology and Medical Biometry, Ulm College, Ulm, GermanyDepartment of Drugs, College of Washington, Seattle, WA, USASina A. Gharib & Guo LiPopulation Well being Sciences, Bristol Medical College, College of Bristol, Bristol, UKRaquel Granell & John HendersonMRC Integrative Epidemiology Unit, College of Bristol, Bristol, UKRaquel Granell & John HendersonAsthma and Airway Illness Analysis Middle and BIO5 Institute, College of Arizona, Tucson, AZ, USAPenelope E. Graves & Fernando J. MartinezdeCODE genetics, Amgen Inc., Reykjavik, IcelandDaniel F. Gudbjartsson, Ingileif Jonsdottir, Kari Stefansson, Gudmar Thorleifsson & Unnur ThorsteinsdottirSchool of Engineering and Pure Sciences, College of Iceland, Reykjavik, IcelandSkin and Allergy Hospital, College of Helsinki, Helsinki, FinlandDepartment of Epidemiology, College of Washington, Seattle, WA, USAInstitute and Outpatient Clinic for Occupational, Social and Environmental Drugs, College Hospital in Munich, Munich, GermanyInstitute of Epidemiology I, Helmholtz Zentrum München, German Analysis Centre for Environmental Well being, Neuherberg, GermanyJoachim Heinrich, Marie Standl & Carla M. T. TieslerNational Institute for Well being and Welfare (THL), Helsinki, FinlandMarkku Heliövaara, Pekka Jousilahti, Mikko Kuokkanen & Veikko SalomaaDepartment of Biostatistics, Epidemiology and Informatics, College of Pennsylvania, Philadelphia, PA, USAHealth Middle, Division of Inside Drugs, Keio College, Tokyo, JapanDivision of Endocrinology and Middle for Fundamental and Translational Weight problems Analysis, Boston Youngsters’s Hospital, Boston, MA, USAJoel N. Hirschhorn & Cameron D. PalmerDepartments of Pediatrics and Genetics, Harvard Medical College, Boston, MA, USADepartment of Epidemiology, Harvard T.H. Chan College of Public Well being, Boston, MA, USAAlbert Hofman & Liming LiangCell Biology Telethon Youngsters Institute, College of Western Australia, Subiaco, Western Australia, AustraliaOntario Institute for Most cancers Analysis, Toronto, Ontario, CanadaAbbVie Inc., Redwood Metropolis, CA, USABusselton Inhabitants Medical Analysis Institute, Perth, Western Australia, AustraliaSchool of Inhabitants and World Well being, College of Western Australia, Nedlands, Western Australia, AustraliaDepartment of Epidemiology and Public Well being, Swiss Tropical and Public Well being Institute, Basel, SwitzerlandMedea Imboden, Ashish Kumar & Nicole Probst-HenschUniversity of Basel, Basel, SwitzerlandMedea Imboden, Ashish Kumar & Nicole Probst-HenschDepartment of Biology, Medical Genetics and Ecology, Kursk State Medical College, Kursk, Russian FederationVladimir Ivanov, Alexey Polonikov & Maria SolodilovaThe Era R Examine Group, Division of Pediatrics and Division of Epidemiology, Erasmus MC–College Medical Middle Rotterdam, Rotterdam, The NetherlandsDepartment of Pulmonary Physiology and Sleep Drugs, Busselton Inhabitants Medical Analysis Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, AustraliaSchool of Drugs and Pharmacology, College of Western Australia, Crawley, Western Australia, AustraliaDepartment of Medical Sciences: Respiratory, Allergy & Sleep Analysis, Uppsala College, Uppsala, SwedenDepartment of Epidemiology and Biostatistics, MRC–PHE Centre for Setting & Well being, College of Public Well being, Imperial School London, London, UKCenter for Life Course Well being Analysis, School of Drugs, College of Oulu, Oulu, FinlandBiocenter Oulu, College of Oulu, Oulu, FinlandUnit of Main Care, Oulu College Hospital, Oulu, FinlandMRC–PHE Centre for Setting and Well being, Imperial School London, London, UKSchool of Science and Well being, Western Sydney College, Sydney, New South Wales, AustraliaFaculty of Drugs, College of Iceland, Reykjavik, IcelandIngileif Jonsdottir, Kari Stefansson & Unnur ThorsteinsdottirDepartment of Pediatric Pneumology and Allergy, College Youngsters’s Hospital Regensburg (KUNO), Regensburg, GermanyMichael Kabesch & Sven MichelDepartment of Scientific Physiology, College of Tampere and Tampere College Hospital, Tampere, FinlandDepartment of Anesthesiology, Perioperative and Ache Drugs, Division of Essential Care Drugs, Boston Youngsters’s Hospital, Boston, MA, USADepartment of Anaesthesia, Harvard Medical College, Boston, MA, USADepartment of Genetics and Elementary Drugs, Bashkir State College, Ufa, Russian FederationAlexandra S. Karunas & Elza KhusnutdinovaUniversity of Groningen, College Medical Middle Groningen, Division of Pediatric Pulmonology and Pediatric Allergology, Beatrix Youngsters’s Hospital, Groningen, The NetherlandsGroningen Analysis Institute for Bronchial asthma and COPD (GRIAC), Groningen, The NetherlandsGerard H. Koppelman, Maartje A. E. Nieuwenhuis, Dirkje S. Postma & Judith M. VonkDepartment of Pediatrics, College of Alberta, Edmonton, Alberta, CanadaRIKEN Middle for Integrative Medical Sciences, Yokohama, JapanMichiaki Kubo, Atsushi Takahashi & Tatsuhiko TsunodaAnn & Robert H. Lurie Youngsters’s Hospital of Chicago, Chicago, IL, USADivison of Allergy and Scientific Immunology, Division of Pediatrics, Northwestern College Feinberg College of Drugs, Chicago, IL, USAInstitute of Environmental Drugs, Karolinska Institutet, Stockholm, SwedenAshish Kumar, Erik Melén, Göran Pershagen & Magnus WickmanInstitute for Molecular Drugs Finland (FIMM), College of Helsinki, Helsinki, FinlandMikko Kuokkanen, Aarno Palotie & Elisabeth WidénPharmaceutical Care Unit, School of Pharmaceutical Sciences, Ghent College, Ghent, BelgiumDepartment of Pulmonary Drugs, College of Turku and Turku College Hospital, Turku, FinlandDépartement des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Quebec, CanadaCentre de Santé et de Companies Sociaux du Saguenay-Lac-Saint-Jean, Saguenay, QC, CanadaMcGill College and Genome Quebec Innovation Centre, Montréal, QC, CanadaPediatric Pneumology and Immunology, Charité Universitätsmedizin, Berlin, GermanyMax-Delbrück-Centrum (MDC) for Molecular Drugs, Berlin, GermanyYoung-Ae Lee & Ingo MarenholzPediatric Allergology, Experimental and Scientific Analysis Middle, Charité Universitätsmedizin, Berlin, GermanyYoung-Ae Lee & Ingo MarenholzDepartment of Scientific Chemistry, Fimlab Laboratories, School of Drugs and Life Sciences, College of Tampere, Tampere, FinlandDepartment of Public Well being Sciences, Henry Ford Well being System, Detroit, MI, USADepartment of Biostatistics, Harvard T.H. Chan College of Public Well being, Boston, MA, USADivision of Common Drugs, College of North Carolina at Chapel Hill, Chapel Hill, NC, USANational Institute of Environmental Well being Sciences, Nationwide Institutes of Well being, Division of Well being and Human Companies, Analysis Triangle Park, NC, USACenter for Public Well being Genomics, College of Virginia, Charlottesville, VA, USAAni Manichaikul & Stephen S. RichMelbourne College of Inhabitants and World Well being, College of Melbourne, Melbourne, Victoria, AustraliaDivision of Allergy & Scientific Immunology, Division of Drugs, Johns Hopkins College, Baltimore, MD, USADepartment of Allergy and Scientific Immunology, Nationwide Analysis Institute for Youngster Well being and Growth, Tokyo, JapanBristol Bioresource Laboratories, College of Social and Neighborhood Drugs, College of Bristol, Bristol, UKDepartment of Scientific Drugs, College of Copenhagen, Copenhagen, DenmarkDepartment of Drugs, Stanford College College of Drugs, Stanford, CA, USACentre for Occupational and Environmental Drugs, Stockholm County Council, Stockholm, SwedenErik Melén & Göran PershagenSachs Youngsters’s Hospital, Stockholm, SwedenDepartment of Respiratory Drugs, Sir Charles Gairdner Hospital, Nedlands, Western Australia, AustraliaSchools of Inhabitants Well being and of Drugs and Pharmacology, College of Western Australia, Perth, Western Australia, AustraliaCenter for Utilized Genomics and Precision Drugs, Duke College College of Drugs, Durham, NC, USAUniversity Medical Middle Groningen, Division of Pulmonology, College of Groningen, Groningen, The NetherlandsMaartje A. E. Nieuwenhuis & Dirkje S. PostmaDepartment of Medical Genetics, School of Drugs, College of Tsukuba, Tsukuba, JapanPulmonary Middle, Division of Drugs, Boston College College of Drugs, Boston, MA, USAThe Nationwide Coronary heart, Lung, and Blood Institute’s Framingham Coronary heart Examine, Framingham, MA, USADepartment of School Pediatrics, Siberian State Medical College, Tomsk, Russian FederationAnalytic and Translational Genetics Unit, Departments of Drugs, of Neurology and of Psychiatry, Massachusetts Common Hospital, Boston, MA, USAThe Stanley Middle for Psychiatric Analysis and Program in Medical and Inhabitants Genetics, Broad Institute, Cambridge, MA, USAChanning Division of Community Drugs, Division of Drugs, Brigham and Ladies’s Hospital and Harvard Medical College, Boston, MA, USABenjamin A. Raby & Scott T. WeissDepartment of Scientific Physiology and Nuclear Drugs, College of Turku and Turku College Hospital, Turku, FinlandDepartment of Medical and Molecular Genetics, King’s School London, London, UKRespiratory Drugs, Murdoch Youngsters’s Analysis Institute, Melbourne, Victoria, AustraliaHubert Division of World Well being, Mory College, Atlanta, GA, USACenter for Inhabitants Well being Analysis, Nationwide Institute of Public Well being, Cuernavaca, MexicoDepartment of Psychiatry, Kern Medical, Bakersfield, CA, USADepartment of Public Well being, Part for Setting, Occupation & Well being, Aarhus College, Aarhus, DenmarkVivi Schlünssen & Torben SigsgaardMRC Epidemiology Unit, College of Cambridge College of Scientific Drugs, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UKRobert Scott, Nick J. Wareham & Jing Hua ZhaoDepartment of School Remedy, Siberian State Medical College, Tomsk, Russian FederationUniversity Hospital of South Manchester, Nationwide Well being Service (NHS) Basis Belief, Manchester, UKInstitut Nationwide de la Santé et de la Recherche Médicale (INSERM) U1209, Institute for Superior Biosciences, Group of Environmental Epidemiology Utilized to Copy and Respiratory Well being, Grenoble, FranceUniversité de Grenoble Alpes/CNRS UMR5309, Institute for Superior Biosciences, Group of Environmental Epidemiology Utilized to Copy and Respiratory Well being, Grenoble, FranceDivision of Pulmonary and Essential Care Drugs, Feinberg College of Drugs, Northwestern College, Chicago, IL, USAPopulation Well being Analysis Institute, St George’s College of London, London, UKNetherlands Healthcare Inspectorate, The Hague, The NetherlandsDepartment of Inside Drugs, Erasmus MC–College Medical Middle Rotterdam, Rotterdam, The NetherlandsBruno H. Stricker & André G. UitterlindenInstitute for Respiratory Well being and Harry Perkins Institute of Medical Analysis, College of Western Australia and The Lung Well being Clinic, Nedlands, Western Australia, AustraliaDivision of Metabolic Illnesses and Dietary Drugs, Dr. von Hauner Youngsters’s Hospital, Ludwig-Maximilians-College of Munich, Munich, GermanyDepartment of Medical Science Arithmetic, Medical Analysis Institute, Tokyo Medical and Dental College, Tokyo, JapanThe Era R Examine Group, Division of Pediatrics, Division of Respiratory Drugs and Division of Epidemiology, Erasmus MC–College Medical Middle Rotterdam, Rotterdam, The NetherlandsDepartment of Pediatrics, Marien-Hospital Wesel, Wesel, GermanyDr. Von Hauner Youngsters’s Hospital, Ludwig Maximilians College Munich, Munich, GermanyGerman Middle for Lung Analysis, Munich, GermanyUniversity of Groningen, College Medical Middle Groningen, Division of Epidemiology, Groningen, The NetherlandsUndergraduate Coaching and Training Middle (UTEC), Jackson Coronary heart Examine, Tougaloo School, Jackson, MI, USACentre for Scientific Analysis Sörmland, Uppsala College, Eskilstuna, SwedenCenter for Well being Coverage and Well being Companies Analysis, Henry Ford Well being System, Detroit, MI, USADepartment of Inside Drugs, Henry Ford Well being System, Detroit, MI, USASchool of Nursing, College of Michigan, Ann Arbor, MI, USADepartment of Human Genetics, College of Chicago, Chicago, IL, USADepartments of Statistics, Human Genetics and Drugs, Part of Genetic Drugs, College of Chicago, Chicago, IL, USAConsortiaAustralian Bronchial asthma Genetics Consortium (AAGC) collaboratorsContributionsTAGC examine administration: F.D., Okay.C.B., W.O.C.C., M.F.M., C.O., and D.L.N.F.D. and D.L.N. designed the examine and wrote the manuscript. F.D., D.L.N., and P.M.-J. designed and carried out the statistical evaluation. Okay.C.B., W.O.C.C., M.F.M., and C.O. designed the examine and wrote the manuscript. M.B., A.V., S. Letort, and H.M. carried out the standard management of the information and carried out statistical evaluation.AAGC (Australia): examine principal investigators (PIs), M.A.F., M.C.M., C.F.R., and P.J.T.; knowledge assortment or evaluation, M.A.F., M.C.M., C.F.R., G.J., and P.J.T.ALLERGEN Canadian Bronchial asthma Main Prevention Examine (CAPPS) and Examine of Bronchial asthma, Genes and the Setting (SAGE): examine PIs, A.B.B., M.C.-Y., D.D., and A.L.Okay.; knowledge assortment or evaluation, D.D. and J.E.P.; examine phenotyping, A.B.B. and M.C.-Y.Saguenay‐Lac‐Saint‐Jean (SLSJ) Examine: examine PIs, C.L. and T.J.H.; examine design and administration, C.L.Evaluation in Inhabitants-based Cohorts of Bronchial asthma Traits (APCAT) Consortium: examine PIs, J.N.H., M.-R.J., and V. Salomaa. Framingham Coronary heart Examine (FHS): examine PI, G.T.O.; knowledge assortment or evaluation, S.V. and Z.G. The European Potential Investigation of Most cancers (EPIC)-Norfolk: examine PI, N.J.W.; knowledge assortment or evaluation, J.H.Z. and R.S. Northern Finland Beginning Cohort of 1966 (NFBC1966): examine PI, M.-R.J.; knowledge assortment or evaluation, A.C.A. and A.R. FINRISK: examine PI, V. Salomaa; knowledge assortment or evaluation, M. Kuokkanen and T. Laitinen. Well being 2000 (H2000) Survey: examine PIs, M.H. and P.J.; knowledge assortment or evaluation, M. Kuokkanen and T.H. Helsinki Beginning Cohort Examine (HBCS): examine PI, J.G.E.; knowledge assortment or evaluation, E.W. and A. Palotie. Younger Finns Examine (YFS): examine PI, O.T.R.; knowledge assortment or evaluation, T. Lehtimäki and M. Kähönen.African Ancestry Research from the Candidate Gene Affiliation Useful resource (CARe) Consortium: examine PIs, J.N.H. and S.S.R.; knowledge assortment or evaluation, C.D.P., D.B.Okay., L.J.S., R.Okay., Okay.M.B., and W.B.W.Multi‐Ethnic Examine of Atherosclerosis (MESA): examine PIs, R.G.B. and S.S.R.; knowledge assortment or evaluation, Okay.M.D. and A.M.Atherosclerosis Danger in Communities Examine (ARIC): examine PI, S.J.L.; knowledge assortment or evaluation, S.J.L. and L.R.L.Cardiovascular Well being Examine (CHS): examine PIs, S.A.G. and S.R.H.; knowledge assortment or evaluation, G.L., S.A.G., and S.R.H.deCode genetics: examine PIs, Okay.S., I.J., D.F.G., U.T., and G.T.; knowledge assortment or evaluation, I.J., D.F.G., and G.T.; examine phenotyping, U.S.B.Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium: PI, H.B. Cophenhagen Potential Examine on Bronchial asthma in Childhood (COPSAC): examine PIs, H.B. and Okay.B.; knowledge evaluation, E. Kreiner and J.W.; examine phenotyping, Okay.B. Danish Nationwide Beginning Cohort (DNBC): examine PI, M.M.; knowledge assortment or evaluation, B.F. and F. Geller. GENERATION R: examine PI, J.C.d.J.; knowledge assortment or evaluation, R.J.P.v.d.V., L.D., and V.W.V.J. GINIplus/LISAplus: examine PI, J. Heinrich; genotyping, knowledge assortment or evaluation, M. Standl and C.M.T.T.; examine phenotyping, J. Heinrich. Manchester Bronchial asthma and Allergy Examine (MAAS): examine PIs, A.S. and A.C.; knowledge assortment or evaluation, J.A.C. Western Australian Being pregnant Cohort Examine (RAINE): examine PI, P.H.; knowledge assortment or evaluation, W.A. and C.E.P.British 1958 Beginning Cohort (B58C) Examine: PI and statistical evaluation, D.P.S.EVE Consortium: examine PIs, C.O., D.L.N., Okay.C.B., E. Bleecker, E. Burchard, J. Gauderman, F. Gilliland, S.J.L., F.J.M., D.M., I.R., S.T.W., L.Okay.W., and B.A.R.; knowledge assortment or evaluation, D.L.N., J. Gauderman, S.J.L., D.M., D.G.T., B.A.R., B.E.H., P.E.G., M.T.S., C.E., B.E.D.-R.-N., J.J.Y., A.M.L., R.A. Myers, R.A. Mathias, and T.H.B.Japanese Grownup Bronchial asthma Analysis Consortium (JAARC): examine PI, T.T.; knowledge assortment or evaluation, T.T., A.T., and M. Kubo.Japan Pediatric Bronchial asthma Consortium (JPAC): examine PI, E.N.; knowledge assortment or evaluation, H.H. and Okay.M.GABRIEL Consortium: examine PIs, W.O.C.C. and E.V.M.; genotyping, M.L.; knowledge evaluation, E.B., F.D., M.F., and D.P.S. Epidemiological examine on the Genetics and Setting of Bronchial asthma (EGEA): examine PIs, V. Siroux and F.D.; genotyping, knowledge assortment or evaluation, M.L. and E. Bouzigon. Avon Longitudinal Examine of Mother and father and Youngsters (ALSPAC): examine PI, J. Henderson; genotyping, knowledge assortment or evaluation, W.L.M. and R.G.; examine phenotyping, J. Henderson. European Neighborhood Respiratory Well being Survey (ECRHS): examine PI, D.J.; knowledge assortment or evaluation, C.J. and J. Heinrich. Youngsters, Allergy, Milieu, Stockholm, Epidemiology (BAMSE) examine: examine PIs, E.M., M.W., and G.P. Busselton Well being Examine: examine PIs, A.W.M., A.J., and J.B.; genotyping, knowledge assortment or evaluation, A.W.M., A.J., J. Hui, and J.B. GABRIEL Superior Surveys: examine PI, E.V.M.; knowledge assortment or evaluation, M. Kabesch and J. Genuneit. Kursk State Medical College (KSMU) Examine: examine PI, A. Polonikov; knowledge assortment or evaluation, M. Solodilova and V.I.; Medical Analysis Council-funded Assortment of Nuclear Households with Bronchial asthma (MRCA-UKC): examine PIs, W.O.C.C. and M.M.; knowledge assortment or evaluation, L. Liang. Multicentre Bronchial asthma Genetics in Childhood Examine (MAGICS): examine PI, M. Kabesch; knowledge assortment or evaluation, A.V.B. and S.M. German Multicentre Allergy Examine (MAS): examine PI, Y.-A.L.; knowledge assortment or evaluation, S. Lau and I.M. Prevention and Incidence of Bronchial asthma and Mite Allergy (PIAMA) cohort : examine PIs, G.H.Okay. and D.S.P.; knowledge assortment or evaluation, G.H.Okay., D.S.P., and U.G. Swiss Cohort Examine on Air Air pollution and Lung and Coronary heart Illnesses in Adults (SAPALDIA): examine PI, N.P.-H.; knowledge assortment or evaluation, M.I. and A.Okay. Tomsk Examine: examine PIs, L.M.O. and V.P.P.; knowledge assortment or evaluation, M.B.F. and P.A.S. UFA Examine: examine PI, E. Khusnutdinova; knowledge assortment or evaluation, A.S.Okay. and Y.F. Industrial Cohorts Analysis Group (INDUSTRIAL): examine PIs, D.H. and T.S.; knowledge assortment or evaluation, I.M.W. and V. Schlünssen. Extreme Bronchial asthma Cohorts (SEVERE): examine PIs, A.B., Okay.F.C., and C.E.B.Netherlands Twin Register (NTR) Examine: examine PI, D.I.B.; genotyping, knowledge assortment or evaluation, J.J.H., H.M., and G.W.Rotterdam Examine: examine PIs, A.H., B.H.S., and G.G.B.; genotyping, knowledge assortment or evaluation, G.G.B., B.H.S., D.W.L., L. Lahousse, and A.G.U.Dutch Bronchial asthma Genetics Consortium (DAGC): examine PIs, G.H.Okay. and D.S.P.; genotyping, knowledge assortment or evaluation, G.H.Okay., D.S.P., J.A., M.A.E.N., and J.M.V.All authors offered essential overview of the manuscript.
Competing pursuits
The authors affiliated with deCODE (D.F.G., I.J., Okay.S., U.T., and G.T.) are staff of deCODE genetics/Amgen. All different coauthors don’t have any conflicts of curiosity to declare.
Corresponding authorsCorrespondence to
Florence Demenais or Dan L. Nicolae.

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