Study preserves hopes for Roche's Tecentriq in lung cancer

Monday, June 25, 2018 12:15 a.m. CDT

By John Miller
ZURICH (Reuters) – Swiss drugmaker Roche’s hopes of getting the primary immunotherapy cocktail to be accredited as an preliminary therapy for an aggressive type of lung most cancers remained intact on Monday after a trial confirmed constructive survival information.
The corporate mentioned Tecentriq, mixed with chemotherapy, considerably boosted general survival of sufferers with beforehand untreated extensive-stage small cell lung most cancers in contrast with chemotherapy alone.
The combination additionally helped sufferers survive longer with out their illness getting worse, Sandra Horning, Roche’s chief medical officer, mentioned in a press release.
With rival drugs Keytruda from Merck beating Roche’s immunotherapy various to the punch in different, extra frequent varieties lung most cancers, the Swiss firm is continuous efforts to show Tecentriq’s deserves in hopes of being first in rarer forms of the illness.
Small cell lung cancers account for 10-15 % of all lung cancers, based on the American Most cancers Society.
“These are the first positive Phase III survival results for any immunotherapy-based combination in the initial treatment of extensive-stage small cell lung cancer,” Horning mentioned.
Roche shares have been seen rising 1.1 %, based on pre-market indications.
Particular survival information from the IMpower 133 examine weren’t given, with the corporate planning to launch the numbers at a medical convention. Nonetheless, it emphasised the outcomes have been “clinically meaningful”.
Baader Helvea analysts mentioned successful a “first mover advantage” within the indication would seemingly finally add $1.5 billion to Roche’s Tecentriq gross sales.
“We see Tecentriq gaining momentum in lung cancer,” mentioned Baader analyst Bruno Bulic.
To this point, outcomes have been lackluster.
Tecentriq had 139 million Swiss francs ($140.6 million) in income within the first quarter, only a tenth of that posted by Keytruda and Bristol-Myers Squibb’s Opdivo, related immunotherapies that work by serving to the physique’s personal protection mechanisms higher detect and assault tumors.
Tecentriq is a key a part of Roche’s technique of introducing newer medicine to assist make up for falling gross sales of its $21 billion oncology trio of Rituxan, Herceptin and Avastin that’s going by patent losses that expose them to cheaper copies, grabbing a giant share of the market.

(Reporting by John Miller; Enhancing by Michael Shields)

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